Green tea protects against memory deficits related to maternal deprivation

Autor: Jefferson Menezes, Mauren Assis Souza, Pâmela Billig Mello-Carpes, Ben-Hur Souto das Neves
Rok vydání: 2017
Předmět:
Male
Pain Threshold
0301 basic medicine
Gerontology
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Hippocampus
Experimental and Cognitive Psychology
Oxidative phosphorylation
Hippocampal formation
medicine.disease_cause
Camellia sinensis
Catechin
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Internal medicine
medicine
Animals
Maze Learning
Chromatography
High Pressure Liquid
chemistry.chemical_classification
Analysis of Variance
Memory Disorders
Maternal deprivation
Reactive oxygen species
Maternal Deprivation
Age Factors
Recognition
Psychology
Glutathione
Rats
030104 developmental biology
Endocrinology
Animals
Newborn
chemistry
Acetylcholinesterase
Exploratory Behavior
Female
Lipid Peroxidation
Reactive Oxygen Species
Psychology
030217 neurology & neurosurgery
Oxidative stress
Zdroj: Physiology & Behavior. 182:121-127
ISSN: 0031-9384
DOI: 10.1016/j.physbeh.2017.10.010
Popis: Maternal deprivation (MD) in early life affects the development of the brain, causing cognitive losses in adulthood. Oxidative imbalance may be one of the factors that trigger these deficits. Therapies with antioxidant components, like green tea from Camellia sinensis (GT) has been used to treat or prevent memory deficits in a variety of conditions related to oxidative stress. Here we demonstrate that memory deficits caused by MD can be prevented by GT antioxidant activity in hippocampus. Pregnant female rats were used. Her puppies were submitted to MD and intake of GT. Recognition and aversive memory were evaluated, as well as hippocampal oxidative status. Data showed that MD prejudice short and long-term recognition and aversive memory and that GT protected memory. Hippocampal reactive oxygen species levels were increased in MD rats; this increase was avoided by GT supplementation. GSH was decreased on hippocampus MD rats. GT did not avoid GSH decrease, but promote the increase of total antioxidant capacity in MD rats' hippocampus. In conclusion, GT protects against memory deficits related to MD, and one of the implicated mechanism seems to be the antioxidant effects of GT.
Databáze: OpenAIRE
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