Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis
| Autor: | Jicheng Wu, Shen Hu, Chongran Sun, Kefeng Ding, Lihong Zhang, Liquan Wang, Jinxia Xin, Ben Wang |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
tumor circulome Medicine (miscellaneous) Review Extracellular vesicles Circulating Tumor DNA 03 medical and health sciences Tumor Biomarkers Extracellular Vesicles 0302 clinical medicine Circulating tumor cell Neoplasms Cancer screening Biomarkers Tumor tumor screening Medicine Diagnostic biomarker Humans Routine clinical practice Liquid biopsy Pharmacology Toxicology and Pharmaceutics (miscellaneous) Early Detection of Cancer business.industry Liquid Biopsy Cancer medicine.disease Neoplastic Cells Circulating Prognosis 030104 developmental biology 030220 oncology & carcinogenesis Cancer research business |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| Popis: | Liquid biopsy is a convenient, fast, non-invasive and reproducible sampling method that can dynamically reflect the changes in tumor gene expression profile, and provide a robust basis for individualized therapy and early diagnosis of cancer. Circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) are the currently approved diagnostic biomarkers for screening cancer patients. In addition, tumor-derived extracellular vesicles (tdEVs), circulating tumor-derived proteins, circulating tumor RNA (ctRNA) and tumor-bearing platelets (TEPs) are other components of liquid biopsies with diagnostic potential. In this review, we have discussed the clinical applications of these biomarkers, and the factors that limit their implementation in routine clinical practice. In addition, the most recent developments in the isolation and analysis of circulating tumor biomarkers have been summarized, and the potential of non-blood liquid biopsies in tumor diagnostics has also been discussed. |
| Databáze: | OpenAIRE |
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