Antioxidant effect of caffeic acid phenethyl ester in experimentally induced periodontitis
| Autor: | Esra Demir, Feyza Otan Özden, Birşen Bilgici, Müge Lütfioğlu |
|---|---|
| Přispěvatelé: | Diş Hekimliği Fakültesi, DEMİR, ESRA |
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
medicine.medical_treatment Total Oxidant Status education Pharmacology medicine.disease_cause Antioxidants 03 medical and health sciences chemistry.chemical_compound Caffeic Acids 0302 clinical medicine Caffeic Acid Phenethyl Ester Cape medicine Animals Periodontitis Caffeic acid phenethyl ester General Dentistry health care economics and organizations Experimental Periodontitis Gingival tissue business.industry virus diseases 030206 dentistry Phenylethyl Alcohol medicine.disease Rats Oxidative Stress Antioxidant capacity chemistry 030220 oncology & carcinogenesis population characteristics Total Antioxidant Status business geographic locations Oxidative stress |
| Zdroj: | Clinical Oral Investigations. 25:4959-4966 |
| ISSN: | 1436-3771 1432-6981 |
| Popis: | Objectives: The aim of the present study was to evaluate the antioxidant effect of systemically administered caffeic acid phenethyl ester (CAPE) in periodontitis. Materials and methods: Forty rats were randomly divided into four groups: control, lipopolysaccharide-induced experimental periodontitis (LPS), CAPE 5: LPS+5 μmol/kg/day CAPE, and CAPE 10: LPS+10 μmol/kg/day CAPE. Following lipopolysaccharide-induced experimental periodontitis, CAPE was administered intraperitoneally for 28 days. Gingival and serumal total antioxidant status (TAS) and total oxidant status (TOS) were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: Gingival tissue TAS was significantly higher with CAPE application compared with the LPS group and was highest in the CAPE 10 group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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