Individual trajectories of cognitive performance in first episode psychosis: a 2-year follow-up study
| Autor: | Isabel Morales-Muñoz, Iluminada Corripio, Eduardo Jesús Aguilar, Ramón Landin-Romero, LETICIA GARCIA-ALVAREZ, ANGELA IBAÑEZ, Miquel Bioque, Vicent Balanzá-Martínez, Anna Alonso, Ana María González-Pinto, Gisela Mezquida, Edith Pomarol-Clotet, Leyre Urigüen, Salvador Sarró, Jose Menchon, Ángel Luis Del Rey Mejías, Ana Maria Sánchez-Torres, Silvia Amoretti, Jose Manuel Lopez-Ilundain, BIBIANA CABRERA, Manuel J. Cuesta, JESSICA MERCHÁN NARANJO, Itxaso González-Ortega, Miquel Bernardo, Rafael Segarra, Anna Mane santacana, Eduard Vieta |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male First episode psychosis Adolescent Psychological intervention Neuropsychological Tests 03 medical and health sciences Executive Function Young Adult 0302 clinical medicine Cognition medicine Reliable change index Humans Pharmacology (medical) Attention Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Set (psychology) Biological Psychiatry business.industry Neuropsychology General Medicine medicine.disease Clinically significant change Regression 030227 psychiatry Psychiatry and Mental health Psychotic Disorders Schizophrenia Longitudinal Disease Progression Female Analysis of variance business 030217 neurology & neurosurgery Clinical psychology Follow-Up Studies |
| Zdroj: | European archives of psychiatry and clinical neuroscience r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu |
| ISSN: | 1433-8491 0940-1334 |
| Popis: | Individual changes over time in cognition in patients with psychotic disorders have been studied very little, especially in the case of first episode psychosis (FEP). We aimed to establish whether change in individual trajectories in cognition over 2 years of a sample of 159 FEP patients was reliable and clinically significant, using the reliable change index (RCI) and clinically significant change (CSC) methods. We also studied a sample of 151 matched healthy controls. Patients and controls were assessed with a set of neuropsychological tests, as well as premorbid, clinical and functionality measures. We analysed the course of cognitive measures over time, using analysis of variance, and the individual trajectories in the cognitive measures with the regression-based RCI (RCI(SRB)) and the CSC. The RCI(SRB) showed that between 5.4 and 31.2% of the patients showed deterioration patterns, and between 0.6 and 8.8% showed improvement patterns in these tests over time. Patients showing better cognitive profiles according to RCI(SRB) (worsening in zero to two cognitive measures) showed better premorbid, clinical and functional profiles than patients showing deterioration patterns in more than three tests. When combining RCI(SRB) and CSC values, we found that less than 10% of patients showed improvement or deterioration patterns in executive function and attention measures. These results support the view that cognitive impairments are stable over the first 2 years of illness, but also that the analysis of individual trajectories could help to identify a subgroup of patients with particular phenotypes, who may require specific interventions. |
| Databáze: | OpenAIRE |
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