Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review
| Autor: | Antonio González-Sarrías, Claus Schneider, José Moisés Laparra-Llopis, Juan Carlos Espín, Juan Antonio Giménez-Bastida |
|---|---|
| Přispěvatelé: | Ministerio de Ciencia e Innovación (España), European Commission, National Institutes of Health (US) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Leukotrienes medicine.drug_class QH301-705.5 Lipoxygenase Anti-Inflammatory Agents Review Resveratrol Pharmacology Catalysis Anti-inflammatory Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Phenols medicine Caffeic acid Animals Humans Lipoxygenase Inhibitors 5-LOX Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Hemiketals Spectroscopy Inflammation biology Organic Chemistry Polyphenols General Medicine Lipid signaling 3. Good health Computer Science Applications Nordihydroguaiaretic acid Chemistry 030104 developmental biology chemistry Arachidonic acid 030220 oncology & carcinogenesis Arachidonate 5-lipoxygenase Curcumin biology.protein Hydroxytyrosol Eicosanoids |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 7937, p 7937 (2021) International Journal of Molecular Sciences |
| Popis: | This article belongs to the Collection Feature Papers in Bioactives and Nutraceuticals. 5-Lipoxygenase (5-LOX) plays a key role in inflammation through the biosynthesis of leukotrienes and other lipid mediators. Current evidence suggests that dietary (poly)phenols exert a beneficial impact on human health through anti-inflammatory activities. Their mechanisms of action have mostly been associated with the modulation of pro-inflammatory cytokines (TNF-α, IL-1β), prostaglandins (PGE2), and the interaction with NF-κB and cyclooxygenase 2 (COX-2) pathways. Much less is known about the 5-lipoxygenase (5-LOX) pathway as a target of dietary (poly)phenols. This systematic review aimed to summarize how dietary (poly)phenols target the 5-LOX pathway in preclinical and human studies. The number of studies identified is low (5, 24, and 127 human, animal, and cellular studies, respectively) compared to the thousands of studies focusing on the COX-2 pathway. Some (poly)phenolics such as caffeic acid, hydroxytyrosol, resveratrol, curcumin, nordihydroguaiaretic acid (NDGA), and quercetin have been reported to reduce the formation of 5-LOX eicosanoids in vitro. However, the in vivo evidence is inconclusive because of the low number of studies and the difficulty of attributing effects to (poly)phenols. Therefore, increasing the number of studies targeting the 5-LOX pathway would largely expand our knowledge on the anti-inflammatory mechanisms of (poly)phenols. This research was supported by the project PID2019-103914RB-I00 from the Ministry of Science and Innovation (MICINN, Spain). J.A.G.-B. was supported by a Standard European Marie Curie Fellowship from the European Commission. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 838991. CS is supported by NIH awards GM076592 and GM118412. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|