Fast Detection of Entacapone by a Lanthanide–Organic Framework with Rhombic Channels
| Autor: | Zhonghang Chen, Hui Min, Wei Shi, Shuangyan Wu, Peng Cheng, Zongsu Han, Tiankai Sun |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lanthanide
Detection limit Overtreatment education Organic Chemistry Catechols chemistry.chemical_element General Chemistry Catechol O-Methyltransferase Photochemistry Lanthanoid Series Elements Catalysis Photoinduced electron transfer chemistry Nitriles otorhinolaryngologic diseases medicine Humans Entacapone Selectivity Europium Luminescence Transferase inhibitor medicine.drug |
| Zdroj: | Chemistry – A European Journal. 27:17459-17464 |
| ISSN: | 1521-3765 0947-6539 |
| Popis: | Entacapone (ENT) is a powerful catechol-O-methyl transferase inhibitor that is used for the diagnosis and treatment of Parkinson's syndrome, but the amount used must be well controlled to avoid overtreatment and side effect. Fast and selective detection of ENT needs well-matched energy levels and well-designed sensor-ENT interaction which is highly challenging. In this work, a water stable europium-based metal-organic framework (Eu-TDA) was synthesized to detect ENT by luminescence with excellent reusability and selectivity in the presence of main coexisting and interference species of plasma with a limit of detection of 5.01 μM. The experimental results showed that the luminescence of Eu-TDA can be effectively quenched by ENT via well-designed photoinduced electron transfer mechanism and internal filtration effect mechanism in the system. |
| Databáze: | OpenAIRE |
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