Time to Onset of Paresthesia Among Community Members Exposed to the World Trade Center Disaster
| Autor: | Michael Marmor, Yongzhao Shao, Joan Reibman, Bin Wang, Sujata Thawani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Health Toxicology and Mutagenesis lcsh:Medicine complex mixtures Article Disasters paresthesia 03 medical and health sciences 0302 clinical medicine Risk Factors Humans Medicine 030212 general & internal medicine Depression (differential diagnoses) Aged Proportional Hazards Models 2. Zero hunger business.industry Proportional hazards model neuropathic symptoms Confounding Hazard ratio lcsh:R Public Health Environmental and Occupational Health World trade center Dust Environmental Exposure Middle Aged 030210 environmental & occupational health humanities 3. Good health Anxiety Female Observational study September 11 Terrorist Attacks medicine.symptom business Body mass index World Trade Center exposure Demography Cox regression hazard function |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 16, Iss 8, p 1429 (2019) International Journal of Environmental Research and Public Health Volume 16 Issue 8 |
| ISSN: | 1660-4601 |
| Popis: | We examined whether time to onset of paresthesia was associated with indicators of severity of World Trade Center (WTC) exposure. We analyzed data from 3411 patients from the Bellevue Hospital&mdash WTC Environmental Health Center. Paresthesia was defined as present if the symptom occurred in the lower extremities with frequency &ldquo often&rdquo or &ldquo almost continuous.&rdquo We plotted hazard functions and used the log-rank test to compare time to onset of paresthesia between different exposure groups. We also used Cox regression analysis to examine risk factors for time-to-paresthesia after 9/11/2001 and calculate hazard ratios adjusted for potential confounders. We found significantly elevated hazard ratios for paresthesia for (a) working in a job that required cleaning of WTC dust in the workplace and (b) being heavily exposed to WTC dust on September 11, 2001, after adjusting for age, race/ethnicity, depression, anxiety, post-traumatic stress disorder, and body mass index. These observational data are consistent with the hypothesis that exposure to WTC dust or some other aspect of cleaning WTC dust in the workplace, is associated with neuropathy and paresthesia. Further neurological evaluations of this and other WTC-exposed populations is warranted. |
| Databáze: | OpenAIRE |
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