Infarction Size, Interleukin-6, and Their Interaction Are Predictors of Short-Term Stroke Outcome in Young Egyptian Adults

Autor: Ahmed F. Elsaid, Rasha M. Fahmi
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Time Factors
Infarction
Disability Evaluation
0302 clinical medicine
Risk Factors
Prevalence
Age of Onset
Young adult
Stroke
Likelihood Functions
medicine.diagnostic_test
biology
Incidence (epidemiology)
Rehabilitation
Brain
Middle Aged
Prognosis
Magnetic Resonance Imaging
Egypt
Female
Cardiology and Cardiovascular Medicine
Adult
Brain Infarction
medicine.medical_specialty
Adolescent
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
cardiovascular diseases
Interleukin 6
Interleukin-6
business.industry
Case-control study
Bayes Theorem
Magnetic resonance imaging
medicine.disease
030104 developmental biology
Case-Control Studies
Linear Models
Physical therapy
biology.protein
Surgery
Neurology (clinical)
Age of onset
Tomography
X-Ray Computed
business
Biomarkers
030217 neurology & neurosurgery
Zdroj: Journal of Stroke and Cerebrovascular Diseases. 25:2475-2481
ISSN: 1052-3057
DOI: 10.1016/j.jstrokecerebrovasdis.2016.06.021
Popis: Background A trend of increasing incidence of first-ever cerebral ischemic stroke in young adults has been recently reported. The current study was conducted with the objective of identifying independent predictors of short-term outcome of first-ever cerebral ischemic stroke affecting young Egyptian adults. Methods The present hospital-based study included 50 patients, 23 males and 27 females, aged 18-45 years, with first-ever ischemic stroke confirmed by computed tomography (CT) and magnetic resonance imaging. Twenty healthy age- and sex-matched random control subjects were included to set the reference laboratory values. Detailed medical, neurological, and laboratory data were collected. Stroke severity and short-term stroke outcome were assessed using the Canadian Neurological Scale and the National Institutes of Health Stroke Scale (NIHSS), respectively. Results High prevalence of modifiable risk factors was observed in young Egyptian adults affected with first-ever ischemic cerebral stroke. Although all studied risk factors were significantly correlated with NIHSS score, multiple regression analysis revealed that only infarction size (CT size), interleukin-6 (IL-6), and their synergistic interaction were the most important predictors of NIHSS stroke outcome. Conclusions IL-6 and infarction size were independent predictors of short-term stroke outcome in young Egyptian adults. Synergistic interaction of IL-6 with infarction size suggests an investigative value for assessing serum IL-6 level and a therapeutic benefit for its reduction during the course of early ischemic stroke treatment.
Databáze: OpenAIRE
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