ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice
| Autor: | P. Moreau, John J. Renger, Christian Kelche, Jean-Bastien Bott, Celina Zerbinatti, Chantal Mathis, Jean-Christophe Cassel |
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| Rok vydání: | 2012 |
| Předmět: |
Apolipoprotein E
Male Behavior Animal Apolipoprotein E4 Apolipoprotein E3 Morris water navigation task Cognition Genetic Pleiotropy Mice Transgenic Normal aging Mice Inbred C57BL Behavioral Neuroscience Mice Memory Space Perception Animals Cognitive decline Allele Young adult Psychology Maze Learning Neuroscience |
| Zdroj: | Behavioural brain research. 243 |
| ISSN: | 1872-7549 |
| Popis: | The APOE-ɛ4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-ɛ4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-ɛ4 on cognitive functions. |
| Databáze: | OpenAIRE |
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