Influenza vaccine effectiveness: Maintained protection throughout the duration of influenza seasons 2010-2011 through 2013-2014

Autor: Anthony W. Hawksworth, Christopher A. Myers, Gary T. Brice, Jennifer M. Radin, Michelle N Ricketts, Erin Hansen
Rok vydání: 2015
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Adolescent
Influenza vaccine
Respiratory Tract Diseases
Logistic regression
Herd immunity
03 medical and health sciences
Young Adult
0302 clinical medicine
Immunology and Microbiology(all)
Internal medicine
Influenza
Human
Medicine
Live attenuated influenza vaccine
Humans
030212 general & internal medicine
Postvaccination
Child
Vaccine Potency
Vaccine effectiveness
General Veterinary
General Immunology and Microbiology
business.industry
Public Health
Environmental and Occupational Health
Infant
Newborn
Antigenic shift
Infant
Odds ratio
Middle Aged
veterinary(all)
Influenza
Confidence interval
Vaccination
030104 developmental biology
Infectious Diseases
Logistic Models
Influenza Vaccines
Child
Preschool
Immunology
Molecular Medicine
Female
Age groups
business
Zdroj: Vaccine. 34(33)
ISSN: 1873-2518
Popis: Background Factors, such as age, comorbidities, vaccine type, herd immunity, previous influenza exposure, and antigenic shift may impact the immune response to the influenza vaccine, protection against circulating strains, and antibody waning. Evaluating vaccine effectiveness (VE) is important for informing timing of vaccine administration and evaluating overall vaccine benefit. Methods VE was assessed using febrile respiratory illness surveillance among Department of Defense non-active duty beneficiaries from influenza seasons 2010–2011 through 2013–2014. Respiratory specimens were taken from participants meeting the case definition and tested by polymerase chain reaction for influenza. VE was calculated using logistic regression and by taking 1 minus the odds ratio of being vaccinated in the laboratory confirmed positive influenza cases versus laboratory confirmed negative controls. Results This study included 1486 participants. We found an overall adjusted VE that provided significant and fairly consistent protection ranging from 54% to 67% during 0–180 days postvaccination. This VE dropped to −11% (95% confidence interval: −102% to 39%) during 181–365 days. Conclusions Our study found moderate VE up to 6 months postvaccination. Since the influenza season starts at different times each year, optimal timing is difficult to predict. Consequently, early influenza vaccination may still offer the best overall protection.
Databáze: OpenAIRE
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