ASPMpredicts poor prognosis and regulates cell proliferation in bladder cancer
| Autor: | Gao Zhenya, Zhuo Ye, Shi-Jie Yao, Yu Fang, Jia Huanxia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Poor prognosis Microcephaly Carcinogenesis Down-Regulation Mice Nude Nerve Tissue Proteins ASPM 03 medical and health sciences High morbidity 0302 clinical medicine Cell Line Tumor Animals Humans Medicine Neoplasm Invasiveness RNA Small Interfering skin and connective tissue diseases Gene Aged Cell Proliferation Mice Inbred BALB C Gene knockdown Bladder cancer business.industry Cell growth Muscles General Medicine Middle Aged Prognosis medicine.disease Gene Expression Regulation Neoplastic Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Cancer research Female 030211 gastroenterology & hepatology business |
| Zdroj: | The Kaohsiung Journal of Medical Sciences. 36:1021-1029 |
| ISSN: | 2410-8650 1607-551X |
| DOI: | 10.1002/kjm2.12284 |
| Popis: | Bladder cancer (BCa) is one of the most common malignancies with high morbidity and mortality worldwide. In recent years, it is of great importance to investigate the molecular etiology associated with of BCa. Abnormal spindle-like microcephaly associated gene (ASPM) is the human orthologous of the Drosophila abnormal spindle (asp) and the most commonly mutated gene of autosomal recessive primary microcephaly. ASPM is overexpressed in several types of cancer cell lines and affects the progression and development of multiple types of cancers. However, its possible role in BCa progression is still unclear. Herein, we demonstrated the possible involvement of ASPM in the progression of BCa. We noticed that high expression of ASPM was positively associated with the poor prognosis. Its knockdown could significantly inhibit the proliferation of BCa cells in vitro and in mice. Therefore, we thought ASPM could act as a promising therapeutic target for BCa. |
| Databáze: | OpenAIRE |
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