Influence of dietary fat and di-2-ethylhexyl phthalate on tissue lipids in rats
| Autor: | Priscilla I. Caasi, Michael S. Stein, Padmanabhan P. Nair |
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| Předmět: |
Male
endocrine system medicine.medical_specialty Vinyl Compounds Phthalic Acids Medicine (miscellaneous) Adipose tissue Food Contamination Biology Kidney Body weight chemistry.chemical_compound Internal medicine medicine Animals Dietary fat Epididymis Nutrition and Dietetics Myocardium Body Weight Phthalate Drug Synergism Esters Heart Lipid metabolism Organ Size Lipid Metabolism Dietary Fats Rats medicine.anatomical_structure Endocrinology Adipose Tissue Liver Basal (medicine) chemistry Animal Nutritional Physiological Phenomena Deficiency Diseases Oxidation-Reduction Plastics |
| Zdroj: | Europe PubMed Central |
| Popis: | Di-2-ethylhexyl phthalate (DEHP) is known to be widely distributed in the food chain, and previous studies have identified DEHP as a constituent of heart muscle mitochondrial lipids. The present paper describes an interaction between dietary DEHP and fat on gain in body weight and on the organ weights and lipid content of liver, heart and kidney in rats. Groups of rats were fed a basal fat-free diet supple mented with either 0.1% DEHP or 4% stripped lard or both for a period of 44 days. Dietary DEHP caused an increase in liver weight irrespective of the fat content in the diet. Although, in the absence of dietary fat, DEHP did not significantly change the body weight and the weight of the epididymal fat pad, with the addition of dietary fat, DEHP potentiated the growth-promoting effect of the fat itself, indicating the existence of an interaction between the two dietary constituents. Among the three organs examined for DEHP content, the liver was the only tissue in which DEHP failed to accumulate as a result of dietary supplementation with this substance. Furthermore, dietary fat and DEHP acted synergistically in increasing the total lipid content of the liver. These observations strongly suggest the existence of an interaction between dietary DEHP and fat on lipid metabolism. J. Nutr. 104: 187-191, 1974. |
| Databáze: | OpenAIRE |
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