| Autor: |
Ying Cheng, Wenhao Qu, Jing Li, Bowen Jia, Yiting Song, Liyu Wang, Tongyu Rui, Qianqian Li, Chengliang Luo |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ACS chemical neuroscience. 13(5) |
| ISSN: |
1948-7193 |
| Popis: |
As a specific ferroptosis marker, transferrin receptor 1 (TfR1) expression is increased following traumatic brain injury (TBI), but the precise role of TfR1 in TBI-induced ferroptosis and neurodegeneration remains to be determined. To further identify more potent ferroptosis inhibitors and effective targets for treating TBI, our study aims at investigating the effects of TfR1 on ferroptosis in a mouse TBI model using ferristatin II (an iron uptake and TfR1 inhibitor). The effect of ferristatin II was first verified in the HT-22 cell line |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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