Scaffold-Free 3-D Cell Sheet Technique Bridges the Gap between 2-D Cell Culture and Animal Models
| Autor: | Alaa T. Alshareeda, Ayidah Alghuwainem, Batla Al-Sowayan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Scaffold Computer science Context (language use) Review 02 engineering and technology Suspension culture Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences Tissue engineering In vivo Spheroids Cellular scaffold-based technique Animals Humans Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Cell sheet Tissue Engineering Tissue Scaffolds Drug discovery Organic Chemistry Bioprinting General Medicine 021001 nanoscience & nanotechnology cell sheet technique 3-dimensional (3-d) cell culture Computer Science Applications Cell biology solid tumor model Disease Models Animal 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Cell culture 0210 nano-technology |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 19, p 4926 (2019) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Various tissue engineering techniques have been created in research spanning two centuries, resulting in new opportunities for growing cells in culture and the creation of 3-D tissue-like constructs. These techniques are classified as scaffold-based and scaffold-free techniques. Cell sheet, as a scaffold-free technique, has attracted research interest in the context of drug discovery and tissue repair, because it provides more predictive data for in vivo testing. It is one of the most promising techniques and has the potential to treat degenerative tissues such as heart, kidneys, and liver. In this paper, we argue the advantages of cell sheets as a scaffold-free approach, compared to other techniques, including scaffold-based and scaffold-free techniques such as the classic systemic injection of cell suspension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |