Age-related changes of aquaporin expression patterns in the postnatal rat retina
| Autor: | Erkan Söğüt, Seda Ocakli, Sevil Cayli, Selim Demir, Hüseyin Ortak, Fatih Ekici, Ufuk Taş |
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| Rok vydání: | 2013 |
| Předmět: |
Retinal degeneration
Aging Histology genetic structures Aquaporin Biology Aquaporins Retina Andrology chemistry.chemical_compound medicine Animals Rats Wistar Ganglion cell layer Retinal pigment epithelium Gene Expression Profiling Gene Expression Regulation Developmental Retinal Inner limiting membrane Cell Biology General Medicine Anatomy medicine.disease Immunohistochemistry eye diseases Rats medicine.anatomical_structure Animals Newborn chemistry Aquaporin 2 Inner nuclear layer sense organs |
| Zdroj: | Acta Histochemica. 115:382-388 |
| ISSN: | 0065-1281 |
| DOI: | 10.1016/j.acthis.2012.09.013 |
| Popis: | Previous studies revealed that the rat retina contains numerous membrane-located water channels, the aquaporins (AQPs). Protein expression patterns of AQP1-4, 6 and 9 were examined by immunohistochemistry. In the present study, we investigated the immunolocalization of AQP1-4, 6 and 9 during postnatal development in the rat retina and examined the effect of age on the tissue distribution of these channels. AQP1, 3, 4, 6 and 9 showed gradually increased expression in rat retinas from postnatal week 1 to week 12, and decreased in the 40-week-old rat retinas. AQP2 expression was barely seen in the first week in rat retinas and displayed a significant increase from week 1 to week 4, however no significant alteration of AQP2 was observed after 4weeks of development. AQP1 and 4 immunoreactivities were present in the inner limiting membrane (ILM), the ganglion cell layer (GCL), inner nuclear layer (INL) and retinal pigment epithelium (RPE) in the 4-, 12- and 40-week-old rat retinas. The RPE, OLM and ILM showed a remarkable expression of AQP1-4, 6 and 9 in the 4, 12 and 40-week-old rat retinas. The reduced expression of AQPs in aged rat retinas may indicate the involvement of AQPs in the pathogenesis of age-related retinal diseases. |
| Databáze: | OpenAIRE |
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