Effects of surgical gloves on postoperative peritoneal adhesions and cytokine expression in a rat model
| Autor: | Amit J. Dwivedi, Steven D. Tennenberg, Yvan J. Silva, Nafisa K. Kuwajerwala |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Rat model Abrasion (medical) Adhesion (medicine) Tissue Adhesions Peritoneal Diseases Risk Assessment Sensitivity and Specificity Rats Sprague-Dawley Peritoneum Laparotomy medicine Animals Surgical Wound Infection Gloves Surgical Probability Analysis of Variance business.industry General Medicine Surgical Gloves medicine.disease Rats Disease Models Animal medicine.anatomical_structure Cytokine Cytokines Surgery Tumor necrosis factor alpha Inflammation Mediators business |
| Zdroj: | American journal of surgery. 188(5) |
| ISSN: | 0002-9610 |
| Popis: | Background Postoperative intraperitoneal adhesions are a major cause of morbidity. We studied the effects of synthetic and latex gloves, and their powders, on postoperative adhesions and cytokine expression in a rat model. Methods Rats underwent laparotomy and cecal abrasion. Rats were grouped based on the glove type used: synthetic powder-free (SPF), synthetic powdered (SP), latex powder-free (LPF), and latex powdered (LP). Serum cytokine (tumor necrosis factor [TNF], interleukin-1 [IL-1], and IL-6) levels were measured. Animals were killed and peritoneal adhesions were graded. Results The SPF group had no adhesions. Adhesions were increased similarly in the SP and LPF groups, and further increased in the LP group. Postoperative serum cytokine levels showed a similar pattern of increases. Conclusions The presence of latex or powder on surgical gloves promoted increased adhesions. Serum cytokine levels correlated with the degree of adhesion formation. Strategies to use latex-free, powder-free gloves and/or limit cytokine expression may decrease peritoneal adhesions in the clinical setting. |
| Databáze: | OpenAIRE |
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