Development of the Primary Antibody Repertoire

Autor:	George D. Yancopoulos, T K Blackwell, Frederick W. Alt
Rok vydání:	1987
Předmět:	Genetics B-Lymphocytes Multidisciplinary Genes Immunoglobulin biology Somatic cell Mechanism (biology) Repertoire Immunoglobulin Variable Region Antibody Diversity Gene rearrangement Antibodies Immune system Gene Expression Regulation biology.protein Animals Humans Antibody Gene
Zdroj:	Science. 238:1079-1087
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.3317825
Popis:	The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139a6b9e4719a68fbbed460a83038e98 https://doi.org/10.1126/science.3317825 Zobrazit plný text záznamu