Calcineurin in development and disease
Autor: | Chunyan Yao, Min Song, Lei Chen |
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Rok vydání: | 2022 |
Předmět: |
0301 basic medicine
Calmodulin fungi food and beverages Cell Biology Biology Biochemistry Cell biology Pathogenesis Serine Calcineurin 03 medical and health sciences 030104 developmental biology 0302 clinical medicine biology.protein Signal transduction Receptor Molecular Biology Transcription factor 030217 neurology & neurosurgery Genetics (clinical) Intracellular |
Zdroj: | Genes & Diseases. 9:915-927 |
ISSN: | 2352-3042 |
Popis: | Calcineurin (CaN) is a unique calcium (Ca2+) and calmodulin (CaM)-dependent serine/threonine phosphatase that becomes activated in the presence of increased intracellular Ca2+ level. CaN then functions to dephosphorylate target substrates including various transcription factors, receptors, and channels. Once activated, the CaN signaling pathway participates in the development of multiple organs as well as the onset and progression of various diseases via regulation of different cellular processes. Here, we review current literature regarding the structural and functional properties of CaN, highlighting its crucial role in the development and pathogenesis of immune system disorders, neurodegenerative diseases, kidney disease, cardiomyopathy and cancer. |
Databáze: | OpenAIRE |
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