Genomic organization of the canine herpesvirus US region
| Autor: | Christine C Tomlinson, Elizabeth J. Haanes |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Genetics
Cancer Research Inverted repeat viruses Genome Viral Biology biology.organism_classification medicine.disease_cause Virology Virus Cell Line Open reading frame Canine herpesvirus Infectious Diseases Herpes simplex virus Dogs Herpesvirus 1 Canid medicine Animals RNA Viral ORFS Equine herpesvirus Cloning Molecular Genomic organization |
| Zdroj: | Virus research. 53(2) |
| ISSN: | 0168-1702 |
| Popis: | Canine herpesvirus (CHV) is an alpha-herpesvirus of limited pathogenicity in healthy adult dogs and infectivity of the virus appears to be largely limited to cells of canine origin. CHV's low virulence and species specificity make it an attractive candidate for a recombinant vaccine vector to protect dogs against a variety of pathogens. As part of the analysis of the CHV genome, the authors determined the complete nucleotide sequence of the CHV US region as well as portions of the flanking inverted repeats. Seven full open reading frames (ORFs) encoding proteins larger than 100 amino acids were identified within, or partially within the CHV US: cUS2, cUS3, cUS4, cUS6, cUS7, cUS8 and cUS9; which are homologs of the herpes simplex virus type-1 US2; protein kinase; gG, gD, gI, gE; and US9 genes, respectively. An eighth ORF was identified in the inverted repeat region, cIR6, a homolog of the equine herpesvirus type-1 IR6 gene. The authors identified and mapped most of the major transcripts for the predicted CHV US ORFs by Northern analysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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