Cognitive dysfunction and amyloid β accumulation are ameliorated by the ingestion of green soybean extract in aged mice
| Autor: | Hitomi Okamura, Hiroyuki Yamamoto, Ryuta Fukutomi, Minoru Hoshino, Kazuaki Iguchi, Shinjiro Imai, Aimi Nakagawa, Kensuke Yasui, Tomokazu Konishi, Keiko Unno, Yuki Katayanagi, Yoshie Narita, Fumiyo Takabayashi, Ayane Hara |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Senescence
Aging medicine.medical_specialty Amyloid Green soybean Medicine (miscellaneous) Hippocampus Endogeny Transcriptome Internal medicine medicine TX341-641 APLP1 Nutrition and Dietetics biology Nutrition. Foods and food supply fungi SAMP10 food and beverages Prostaglandin D2 synthase Amyloid β medicine.anatomical_structure Endocrinology Biochemistry Cerebral cortex biology.protein Cognitive function Food Science |
| Zdroj: | Journal of Functional Foods, Vol 14, Iss, Pp 345-353 (2015) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2015.02.011 |
| Popis: | The effects of soybean extracts were investigated in senescence-accelerated (SAMP10) mice, a mouse model of brain senescence with cognitive dysfunction. Mature soybeans are usually yellow. However, the green soybean retains green color after being ripened. Cognitive functions were significantly better-preserved in aged mice fed green soybean than age-matched control mice with or without yellow soybean feeding. Molecular mechanisms of the beneficial effect of green soybean on brain functions were examined through transcriptome analysis of SAMP10 hippocampus. The high expression of Ptgds was significantly associated with green soybean diet, which encodes lipocalin-type prostaglandin D2 synthase, a putative endogenous amyloid β(Αβ)-chaperone. In consonance, Aplp1 expression was significantly reduced, a member of amyloid precursor proteins. Furthermore, the amount of Aβ 40 and 42 was reduced in the insoluble fraction of cerebral cortex. These results suggest that the intake of green soybean ameliorates cognitive dysfunction of aged mice through the reduction of Aβ accumulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect