5-HT4 receptors, present in piglet atria and sensitive to SDZ 205-557, are absent in papillary muscle
| Autor: | Alain Grosset, Janine Lorrain, Stephen E. O'Connor |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Cardiotonic Agents Swine medicine.drug_class In Vitro Techniques Biology Internal medicine para-Aminobenzoates medicine Animals Heart Atria Receptor Papillary muscle 5-HT receptor Inotropic agent Pharmacology Atrium (architecture) Papillary Muscles Receptor antagonist In vitro Endocrinology medicine.anatomical_structure Receptors Serotonin Circulatory system cardiovascular system Female Serotonin Antagonists 4-Aminobenzoic Acid |
| Zdroj: | European Journal of Pharmacology. 229:105-108 |
| ISSN: | 0014-2999 |
| Popis: | Putative 5-HT 4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD 2 of 6.7. Its effects were antagonised in a selective and competitive manner by the 5-HT 4 receptor antagonist, SDZ 205-557, with a pA 2 of 7.3. In contrast to atrial tissues, piglet papillary muscles were virtually unresponsive to 5-HT 10 −8 −10 −3 M, suggesting that functional cardiac 5-HT 4 receptors are not present in ventricular tissue. |
| Databáze: | OpenAIRE |
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