| Autor: |
Carlo Abbate, Pietro D. Trimarchi, Giorgio G. Fumagalli, Alessia Gallucci, Emanuele Tomasini, Stefania Fracchia, Isabella Rebecchi, Elisabetta Morello, Anna Fontanella, Paola M.R. Parisi, Federica Tartarone, Fabrizio Giunco, Simona Ciccone, Paola Nicolini, Tiziano Lucchi, Beatrice Arosio, Silvia Inglese, Paolo D. Rossi |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Alzheimer's disease : JAD. 91(1) |
| ISSN: |
1875-8908 |
| Popis: |
Background: Alzheimer’s disease (AD) is clinically heterogeneous, including the classical-amnesic (CA-) phenotype and some variants. Objective: We aim to describe a further presentation we (re)named confabulation-misidentification (CM-) phenotype. Methods: We performed a retrospective longitudinal case-series study of 17 AD outpatients with the possible CM-phenotype (CM-ADs). Then, in a cross-sectional study, we compared the CM-ADs to a sample of 30 AD patients with the CA-phenotype (CA-ADs). The primary outcome was the frequency of cognitive and behavioral features. Data were analyzed as differences in percentage by non-parametric Chi Square and mean differences by parametric T-test. Results: Anterograde amnesia (100%) with early confabulation (88.2%), disorientation (88.2%) and non-infrequently retrograde amnesia (64.7%) associated with reduced insight (88.2%), moderate prefrontal executive impairment (94.1%) and attention deficits (82.3%) dominated the CM-phenotype. Neuropsychiatric features with striking misidentification (52.9%), other less-structured delusions (70.6%), and brief hallucinations (64.7%) were present. Marked behavioral disturbances were present early in some patients and very common at later stages. At the baseline, the CM-ADs showed more confabulation (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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