Effects of a Japanese Cuisine-Based Antihypertensive Diet and Fish Oil on Blood Pressure and Its Variability in Participants with Untreated Normal High Blood Pressure or Stage I Hypertension: A Feasibility Randomized Controlled Study
| Autor: | Sayaka Motoi, Seiji Umemoto, Uran Onaka, Reo Kawano, Makoto Mitarai, Atsuko Kawamura, Hiroki Kanazashi, Naoki Honda |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty DASH diet Dietary Approaches To Stop Hypertension 030204 cardiovascular system & hematology law.invention Cohort Studies 03 medical and health sciences 0302 clinical medicine Fish Oils Randomized controlled trial Japan law Internal medicine Dash Internal Medicine medicine Humans Life Style Aged business.industry Biochemistry (medical) Outcome measures Middle Aged University hospital Fish oil Blood pressure Hypertension Feasibility Studies Female Cardiology and Cardiovascular Medicine business Psychosocial 030217 neurology & neurosurgery |
| Zdroj: | Journal of atherosclerosis and thrombosis. 29(2) |
| ISSN: | 1880-3873 |
| Popis: | Aim The Dietary Approaches to Stop Hypertension (DASH) diet is recommended for lowering blood pressure (BP). Our previous single-arm trial revealed that the Japanese cuisine-based DASH (J-DASH) diet (supplying NaCl 8.0 g per day) reduced BP and improved cardiometabolic biomarkers. The present study's primary objective was to test the feasibility of the J-DASH diet based on its effects on the BP and BP variability of subjects with untreated high-normal BP or stage 1 hypertension. Methods The 6-month study period was held from December 2015 to August 2016. The participants were recruited through advertisements in local newspapers and our website and from among randomized participants at Yamaguchi University Hospital. The 2-month treatments included the following: the J-DASH-1 diet 1×/day or the J-DASH-2 diet providing a fish hamburger-patty 2×/day (5 days/week respectively). The control group consumed their usual diets. For the subsequent 4 months, all participants consumed their usual diets. The main outcome measure was the feasibility of the J-DASH diet. We also collected the data of clinic BP and home BP (by automatic BP monitor), cardiometabolic biomarkers, and lifestyle and psychosocial parameters during the intervention phase. We examined behavior changes throughout the study period, and the diets' safety. Results Fifty-one participants were recruited; following screening, 48 met the inclusion criteria and were randomized by central allocation. Eight participants were eliminated based on exclusion criteria, and the 40 participants were randomly allocated to the J-DASH 1 and J-DASH 2 groups (n=13 each) and the usual-diet group (n=14). The participants' mean age was 50 years, and 44% were women. The three groups' clinic BP values were not significantly different, but the home BP values were lower in the J-DASH 1 group and lowest in the J-DASH 2 group compared to the usual-diet group and differed significantly among the three groups throughout the study period (p＜0.0001). The home BP variability was significantly lower in the J-DASH groups compared to the usual-diet group throughout the study period (p＜0.01). The other indices including fish oil showed little differences among the groups throughout the study period. Conclusions The J-DASH diet was feasible to improve home BP and stabilize its variability, and it did so more effectively than the participants' usual diets. |
| Databáze: | OpenAIRE |
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