Associations between handgrip strength and hypertension in relation to circulating CD34-positive cell levels among Japanese older men: a cross-sectional study
| Autor: | Takahiro Maeda, Yasuhiro Nagata, Shin-ya Kawashiri, Hirotomo Yamanashi, Yuji Shimizu, Kenichi Nobusue |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Cross-sectional study Population Cardiovascular risk factors Antigens CD34 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Japan Internal medicine medicine Humans education Aged 030304 developmental biology 0303 health sciences education.field_of_study Hand Strength Cd34 positive cell business.industry Public Health Environmental and Occupational Health General Medicine Odds ratio Middle Aged Confidence interval Cross-Sectional Studies medicine.anatomical_structure Blood pressure Heart Disease Risk Factors Hypertension Cardiology Public aspects of medicine RA1-1270 business Research Article |
| Zdroj: | Environmental Health and Preventive Medicine Environmental Health and Preventive Medicine, Vol 26, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1347-4715 1342-078X |
| DOI: | 10.1186/s12199-021-00982-w |
| Popis: | Background A positive association between handgrip strength and blood pressure has been reported. Since these factors are linked to the condition of the endothelium, the activity of endothelial repair might influence the association between handgrip strength and hypertension. Methods A cross-sectional study was conducted with 257 Japanese men aged 60–69 years who underwent an annual health checkup. As individuals with high level of circulating CD34-positive cells might show active endothelial repair, which plays an important role in vascular homeostasis, participants were stratified by circulating CD34-positive cell levels, using the median value of this population (0.96 cells/μL) as the cutoff. Results Independent of known cardiovascular risk factors, for participants with a high CD34-positive cell, handgrip strength is significantly positively associated with hypertension (odds ratio and 95% confidence interval of hypertension for 1 standard deviation increment of handgrip strength were 1.85 (1.19, 2.88) but not for participants with a low CD34-positive cell (0.91 (0.61, 1.37)). Conclusion The positive association between handgrip strength and hypertension is limited to high CD34-positive cells. This result may help clarify the role of vascular homeostasis in maintaining muscle strength. |
| Databáze: | OpenAIRE |
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