Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort

Autor: Zaccardi, F., Razieh, C., Gillies, C.L., Chudasama, Y., Docherty, A.B., Openshaw, P.J.M., Baillie, J.K., Semple, M.G., Khunti, K., Carson, G., Alex, B., Bach, B., Barclay, W.S., Bogaert, D., Chand, M., da Silva Filipe, A., Hiscox, J.A., Horby, P.W., Ijaz, S., Khoo, S., Klenerman, P., Lim, W.S., Mentzer, A.J., Merson, L., Meynert, A.M., Noursadeghi, M., Palmarini, M., Paxton, W.A., Pollakis, G., Rambaut, A., Sancho-Shimizu, V., Sigfrid, L., Solomon, T., Sriskandan, S., Stuart, D., Tedder, R.S., Thwaites, R.S., Turtle, L.C.W., Zambon, M., Donohue, C., Ewins, J., Oosthuyzen, W., Griffiths, F., Pius, R., Drake, T.M., Fairfield, C.J., Girvan, M., Saviciute, E., Connor, M., Halpin, S., Hendry, R., Scott-Brown, J., Greenhalf, W., Shaw, V., Asiimwe, I.G., Bakshi, S., Bullock, K., Catterall, B.W.A., Dincarslan, O., Dunn, C., Garcia-Dorival, I., Gunning, P., Jensen, R.L., Khandaker, S., Kiy, R.T., Koukorava, C., Lake, A., Lant, S., Latawiec, D., Lavelle-Langham, L., Lefteri, D., Lett, L., Livoti, L.A., Mancini, M., McLauchlan, J., Metelmann, S., Miah, N.S., Penrice-Randal, R., Pilgrim, J., Reynolds, W., Ridley, P.M., Sales, D., Shaw, V.E., Subramaniam, K.S., Szemiel, A., Taggart, A., Trochu, E., van Tonder, L., Adeniji, K., Agranoff, D., Agwuh, K., Ail, D., Alegria, A., Angus, B., Ashish, A., Bari, S., Barlow, G., Barnass, S., Barrett, N., Bassford, C., Beadsworth, M., Bernatoniene, J., Berridge, J., Best, N., Bothma, P., Brealey, D., Brittain-Long, R., Bulteel, N., Burden, T., Burtenshaw, A., Caruth, V., Chambler, D., Chee, N., Chukkambotla, S., Collini, P., Cosgrove, C., Cupitt, J., Cutino-Moguel, M.-T., Dark, P., Dervisevic, S., Donnison, P., Douthwaite, S., DuRand, I., Dushianthan, A., Dyer, T., Eziefula, C., Fegan, C., Finn, A., Godden, J., Goldsmith, A., Hardy, E., Havalda, P., Hawcutt, D.B., Hobrok, M., Holme, A., Hormis, A., Kaliappan, A., Kasipandian, V., Kegg, S., Kelsey, M., Kerrison, C., Kerslake, I., Koch, O., Koduri, G., Koshy, G., Leiner, T., Lillie, P., Limb, J., Linnett, V., MacMahon, M., MacNaughton, E., Mankregod, R., Masson, H., Matovu, E., McCullough, K., McEwen, R., Meda, M., Minton, J., Mirfenderesky, M., Mohandas, K., Mok, Q., Mortimore, K., Moses, S., Mpenge, M., Nagarajan, T., Otahal, I., Pais, M., Panchatsharam, S., Paraiso, H., Pepperell, J., Peters, M., Phull, M., Pintus, S., Pooni, J.S., Post, F., Prout, R., Rae, N., Reschreiter, H., Reynolds, T., Richardson, N., Rousseau, G., Saluja, T., Shanmuga, P., Sizer, J., Snelson, C., Spittle, N., Staines, N., Stambach, T., Subudhi, P., Szakmany, T., Tatham, K., Tridente, A., Tupper-Carey, D., Twagira, M., Vallotton, N., Vincent-Smith, L., Visuvanathan, S., Vuylsteke, A., Waddy, S., Wake, R., Welters, I., Whitehouse, T., Wijesinghe, M., Winchester, S., Wiselka, M., Wolverson, A., Wooton, D.G., Yates, B.
Přispěvatelé: Razieh, Cameron [0000-0003-3597-2945], Semple, Malcolm G. [0000-0001-9700-0418], Apollo - University of Cambridge Repository, Semple, Malcolm G [0000-0001-9700-0418], investigators, ISARIC4C, National Institute for Health Research, Medical Research Council (MRC), GlaxoSmithKline Biologicals, UKRI MRC COVID-19 Rapid Response Call, UK Research and Innovation
Rok vydání: 2021
Předmět:
Male
obesity
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Ethnic group
Medicine (miscellaneous)
Comorbidity
Cohort Studies
0302 clinical medicine
Endocrinology
INFECTION
Ethnicity
Odds Ratio
Medicine
030212 general & internal medicine
Hospital Mortality
Young adult
ISARIC4C investigators
Minority Groups
Nutrition and Dietetics
Epidemiology/Genetics
Middle Aged
Hospitalization
Minority Groups/statistics & numerical data
Cohort
ethnicity
Original Article
Female
Ethnicity/statistics & numerical data
Life Sciences & Biomedicine
Cohort study
Adult
CLINICAL-OUTCOMES
Respiration
Artificial/statistics & numerical data
Critical Care
030209 endocrinology & metabolism
Obesity/ethnology
Endocrinology & Metabolism
BMI
03 medical and health sciences
Young Adult
Humans
Obesity
Hospitalization/statistics & numerical data
Aged
Mechanical ventilation
Science & Technology
Nutrition & Dietetics
business.industry
Critical Care/statistics & numerical data
ISARIC
COVID-19
Odds ratio
Original Articles
medicine.disease
COVID-19/ethnology
Respiration
Artificial
United Kingdom
POINTS
ethnic differences
business
Demography
Zdroj: Obesity (Silver Spring, Md.)
Zaccardi, F, Razieh, C, Gillies, C L, Chudasama, Y, Docherty, A B, Openshaw, P J M, Baillie, J K, Semple, M G, Khunti, K, Carson, G, Alex, B, Bach, B, Barclay, W S, Bogaert, D, Chand, M, da Silva Filipe, A, Hiscox, J A, Horby, P W, Ijaz, S, Khoo, S, Klenerman, P, Lim, W S, Mentzer, A J, Merson, L, Meynert, A M, Noursadeghi, M, Palmarini, M, Paxton, W A, Pollakis, G, Rambaut, A, Sancho-Shimizu, V, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Tedder, R S, Thwaites, R S, Turtle, L C W, Zambon, M, Donohue, C, Ewins, J, Oosthuyzen, W, Griffiths, F, Pius, R, Drake, T M, Fairfield, C J, Girvan, M, Saviciute, E, Connor, M, Halpin, S, Hendry, R, Scott-Brown, J, Greenhalf, W, Shaw, V, Asiimwe, I G, Bakshi, S, Bullock, K, Catterall, B W A, Dincarslan, O, Dunn, C, Garcia-Dorival, I, Greenhalf, W, Gunning, P, Jensen, R L, Khandaker, S, Kiy, R T, Koukorava, C, Lake, A, Lant, S, Latawiec, D, Lavelle-Langham, L, Lefteri, D, Lett, L, Livoti, L A, Mancini, M, McLauchlan, J, Metelmann, S, Miah, N S, Penrice-Randal, R, Pilgrim, J, Reynolds, W, Ridley, P M, Sales, D, Shaw, V E, Subramaniam, K S, Szemiel, A, Taggart, A, Trochu, E, van Tonder, L, Adeniji, K, Agranoff, D, Agwuh, K, Ail, D, Alegria, A, Angus, B, Ashish, A, Bari, S, Barlow, G, Barnass, S, Barrett, N, Bassford, C, Beadsworth, M, Bernatoniene, J, Berridge, J, Best, N, Bothma, P, Brealey, D, Brittain-Long, R, Bulteel, N, Burden, T, Burtenshaw, A, Caruth, V, Chambler, D, Chee, N, Chukkambotla, S, Collini, P, Cosgrove, C, Cupitt, J, Cutino-Moguel, M-T, Dark, P, Dervisevic, S, Donnison, P, Douthwaite, S, DuRand, I, Dushianthan, A, Dyer, T, Eziefula, C, Fegan, C, Finn, A, Godden, J, Goldsmith, A, Hardy, E, Havalda, P, Hawcutt, D B, Hobrok, M, Holme, A, Hormis, A, Kaliappan, A, Kasipandian, V, Kegg, S, Kelsey, M, Kerrison, C, Kerslake, I, Koch, O, Koduri, G, Koshy, G, Leiner, T, Lillie, P, Limb, J, Linnett, V, MacMahon, M, MacNaughton, E, Mankregod, R, Masson, H, Matovu, E, McCullough, K, McEwen, R, Meda, M, Minton, J, Mirfenderesky, M, Mohandas, K, Mok, Q, Mortimore, K, Moses, S, Mpenge, M, Nagarajan, T, Otahal, I, Pais, M, Panchatsharam, S, Paraiso, H, Pepperell, J, Peters, M, Phull, M, Pintus, S, Pooni, J S, Post, F, Prout, R, Rae, N, Reschreiter, H, Reynolds, T, Richardson, N, Rousseau, G, Saluja, T, Shanmuga, P, Sizer, J, Snelson, C, Spittle, N, Staines, N, Stambach, T, Subudhi, P, Szakmany, T, Tatham, K, Tridente, A, Tupper-Carey, D, Twagira, M, Vallotton, N, Vincent-Smith, L, Visuvanathan, S, Vuylsteke, A, Waddy, S, Wake, R, Welters, I, Whitehouse, T, Wijesinghe, M, Winchester, S, Wiselka, M, Wolverson, A, Wooton, D G & Yates, B 2021, ' Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort ', Obesity, vol. 29, no. 7, pp. 1223-1230 . https://doi.org/10.1002/oby.23178
Baillie, J K 2021, ' Obesity, ethnicity and risk of critical care, mechanical ventilation and mortality in patients admitted to hospital with COVID-19 : Analysis of the ISARIC CCP-UK cohort ', Obesity . https://doi.org/10.1002/oby.23178
DOI: 10.17863/cam.73544
Popis: Objective: the aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups.Methods: patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases.Results: of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity.Conclusions: obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.
Databáze: OpenAIRE
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