A new access to quinazolines from simple anilines

Autor:	Adriano Guiotto, Vera Barbieri, P. Manzini, Giovanni Pastorini, Giovanni Marzaro, Adriana Chilin, Samuele Zanatta
Rok vydání:	2006
Předmět:	Aqueous solution synthesis substituent effects Organic Chemistry General Medicine Biochemistry Combinatorial chemistry Potassium ferricyanide chemistry.chemical_compound chemistry Simple (abstract algebra) Drug Discovery Quinazoline Organic chemistry quinazoline Hexamethylenetetramine
Zdroj:	Tetrahedron. 62:12351-12356
ISSN:	0040-4020
Popis:	A new synthetic pathway to quinazolines is described. This new method uses hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH, starting from simple N-protected anilines. The method affords substituted quinazolines with high selectivities and good yields, reducing reaction-time and work-up operations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138c71b3f1a6c214b5d11031560db22a https://doi.org/10.1016/j.tet.2006.09.103 Zobrazit plný text záznamu Full Text from ScienceDirect