Increased platelet, leukocyte, and endothelial cell activity are associated with increased coagulability in patients after total knee arthroplasty
| Autor: | Kyoko Kageyama, Satoru Hashimoto, Masayuki Shibasaki, Yasufumi Nakajima, Toshiki Mizobe |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Endothelium CD40 Ligand Urology Tissue factor Double-Blind Method Leukocytes Humans Medicine Platelet Arthroplasty Replacement Knee Blood Coagulation Aged Whole blood Aged 80 and over Venous Thrombosis business.industry Endothelial Cells Venous Plasma Hematology Venous blood Middle Aged medicine.disease Venous thrombosis medicine.anatomical_structure Anesthesia Female business Platelet factor 4 |
| Zdroj: | Journal of Thrombosis and Haemostasis. 5:738-745 |
| ISSN: | 1538-7836 |
| Popis: | Summary. Background: Orthopedic surgery, especially total knee and total hip arthroplasty, is considered a risk factor for peri-operative venous thromboembolism. Objectives: This study evaluates how accelerated inflammatogenic cellular interactions and the subsequent production of tissue factor and CD40 ligand play an important role in the pathogenesis of venous thromboembolism. Patients and methods: Twenty-four patients undergoing total knee arthroplasty were randomly assigned to groups with (Ti; n = 12) and without (Tn; n = 12) pneumatic tourniquet inflation. Results: Numbers of leukocyte-platelet aggregates, especially those comprising monocytes-platelets in central venous blood from the Ti group, were increased during the peri-operative period (P |
| Databáze: | OpenAIRE |
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