GABA(A) ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety
| Autor: | Kjell Fuxe, Avril Nuche-Bricaire, Minerva Crespo-Ramírez, Candy Flores-Gracia, Ricardo Miledi, Miguel Pérez de la Mora |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Elevated plus maze medicine.medical_specialty Pyridines medicine.medical_treatment Microdialysis Anxiety Motor Activity Bicuculline Amygdala GABAA-rho receptor Seizures Internal medicine medicine Animals GABA-A Receptor Antagonists Rats Wistar Receptor Pharmacology Behavior Animal Dose-Response Relationship Drug Chemistry GABAA receptor musculoskeletal neural and ocular physiology Fear Receptors GABA-A Phosphinic Acids Rats Steroid hormone medicine.anatomical_structure Endocrinology nervous system Mechanism of action Exploratory Behavior medicine.symptom Corticosterone Neuroscience Glucocorticoid medicine.drug |
| Zdroj: | Psychopharmacology. 212(4) |
| ISSN: | 1432-2072 |
| Popis: | Accumulating evidence for the presence of GABA(A) ρ receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained.This work was conducted to study whether GABA(A) ρ receptors may have a putative role in the amygdaloid modulation of fear and anxiety.It was found that the bilateral intra-amygdaloid administration (6-240 pmol/side) of (1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid, a selective GABA(A) ρ receptor antagonist, reduced dose-dependently the exploration of the open arms of the elevated plus-maze without affecting locomotion and increased the plasma levels of corticosterone. In contrast, bicuculline in the dose range used (1.8-60 pmol/side) induced seizures, but had no effects on the exploration of the maze.It is suggested that GABA(A) ρ receptors may have a role in the amygdaloid modulation of fear and anxiety. |
| Databáze: | OpenAIRE |
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