Analysis of multiple sclerosis patients with electrophysiological and structural tests
| Autor: | Zeynep Duru, Mualla Hamurcu, Semra Mungan, Murat Sinan Sarıcaoğlu, Gürdal Orhan |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Optic Neuritis genetic structures Visual Acuity Nerve fiber layer Retinal Pigment Epithelium Audiology 03 medical and health sciences Nerve Fibers 0302 clinical medicine Ophthalmology Electroretinography medicine Humans Outpatient clinic Optic neuritis Evoked potential medicine.diagnostic_test business.industry Multiple sclerosis Optic Nerve Middle Aged medicine.disease eye diseases medicine.anatomical_structure Disease Progression 030221 ophthalmology & optometry Optic nerve Evoked Potentials Visual Female sense organs business Erg Tomography Optical Coherence 030217 neurology & neurosurgery |
| Zdroj: | International Ophthalmology. 37:649-653 |
| ISSN: | 1573-2630 0165-5701 |
| Popis: | We aimed to analyze the effects of progressive myelin loss and neurodegeneration seen in patients with multiple sclerosis (MS) on visual tract with electrophysiological and structural tests. Fifty-one patients diagnosed with MS in the Neurology Department were followed up in neuro-ophthalmology outpatient clinic irrespective of their visual symptoms, and were included in our study. The patients were classified as the ones with the history of optic neuritis (group II) and ones without the history (group I) of optic neuritis. The data, including clinical presentation, retinal nerve fiber layer thickness (RNFLT) measurements, pattern visual evoked potential (pVEP) and flash electro retino grams (ERG) test results, were recorded. In our study, comparison of pVEP test latencies of groups I and II with each other, and with those of healthy subjects revealed statistically significant differences (p 0.05). The analysis of rod functions on ERG did not show any significant changes (p 0.05). However, both groups showed significantly decreased cone b-wave amplitudes, elongation of latencies, and decreased flicker amplitudes on cone and flicker potentials obtained after light adaptation (p 0.05). There was significant thinning in RNFLT of the both groups when compared to the normal standards. The difference between two groups was statistically significant (p 0.05). Axon loss is seen in the optic nerve with subclinical or acute optic neuritis in patients with MS. RNFLT analysis and electrophysiological tests are of great importance in diagnosis of MS, as well as to determine progression and to direct neuroprotective therapy in patients diagnosed with MS. Objective analysis methods gain more importance in the diagnosis and follow-up of MS patients, parallel to technological advancements. |
| Databáze: | OpenAIRE |
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