Management of bioburden with a burn gel that targets nociceptors
| Autor: | Martineau L, Dosch Hm |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Mafenide medicine.medical_specialty Nursing (miscellaneous) medicine.disease_cause Placebo Citric Acid Rats sprague dawley Microbiology Rats Sprague-Dawley Bioburden medicine Animals Mafenide Acetate Acetic Acid business.industry Pseudomonas aeruginosa Nociceptors Wound infection Rats Surgery Drug Combinations Anti-Infective Agents Local Wound Infection Fundamentals and skills Burns business Gels medicine.drug |
| Zdroj: | Journal of Wound Care. 16:157-164 |
| ISSN: | 2052-2916 0969-0700 |
| Popis: | Aim: To assess the effectiveness of RescuDerm, an amorphous, water-soluble burn gel in controlling Pseudomonas aeruginosa growth in rat full-thickness wounds contaminated with 103, 105 or 107 CFU/g tissue. Method: Wounds were treated daily for 72 hours with a placebo gel, a 5% w/w mafenide acetate gel (Maf), or with four modalities of RescuDerm application. Results: All RescuDerm treatments were equally effective within 24 hours in preventing further Pseudomonas aeruginosa growth in wounds contaminated with 103 CFU/g tissue. Pseudomonas aeruginosa levels remained at or below this baseline count for 72 hours in all but one of the RescuDerm treatments. The bioburdens in Maf-treated wounds were negligible, averaging 0.14 ± 0.09 log10 CFU/g tissue. While RescuDerm and Maf remained bacteriostatic in wounds contaminated with 105 CFU/g tissue, this property disappeared at higher bioburdens. Conclusion: RescuDerm can be used for the management of cutaneous injuries sustained in environments deemed marginally or moderately contaminated. Heavily contaminated wounds would require irrigation prior to application to reduce their bioburden below 105 CFU/g tissue. Declaration of interest: This work was partly supported by NociPharm. Defence Research and Development Canada (DRDC) Toronto designed all the experimental protocols. The findings of this study were not constrained by the sponsoring body, and have never been presented at a scientific meeting or in another public context. |
| Databáze: | OpenAIRE |
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