Neutrophils suppress mucosal‐associated invariant T cells in humans
| Autor: | Andrea J. Vernall, James E. Ussher, Joel D. A. Tyndall, Marion Schneider, Rachel F. Hannaway, Anthony J. Kettle, Sara M. de la Harpe, Rajesh Lamichhane |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell type Neutrophils Immunology Cell Communication Mucosal associated invariant T cell Biology Lymphocyte Activation Mucosal-Associated Invariant T Cells Leukocyte Count 03 medical and health sciences 0302 clinical medicine Cell Movement Escherichia coli Humans Immunology and Allergy Immunity Mucosal Pathogen Feedback Physiological Mucous Membrane Tumor Necrosis Factor-alpha MAIT Cells Hydrogen Peroxide Coculture Techniques Cell biology 030104 developmental biology Liver Cell activation 030215 immunology |
| Zdroj: | European Journal of Immunology. 50:643-655 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.201948394 |
| Popis: | Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that are abundant in mucosal tissues and the liver where they can respond rapidly to a broad range of riboflavin producing bacterial and fungal pathogens. Neutrophils, which are recruited early to sites of infection, play a nonredundant role in pathogen clearance and are crucial for controlling infection. The interaction of these two cell types is poorly studied. Here, we investigated both the effect of neutrophils on MAIT cell activation and the effect of activated MAIT cells on neutrophils. We show that neutrophils suppress the activation of MAIT cells by a cell-contact and hydrogen peroxide dependent mechanism. Moreover, highly activated MAIT cells were able to produce high levels of TNF-α that induced neutrophil death. We therefore provide evidence for a negative regulatory feedback mechanism in which neutrophils prevent overactivation of MAIT cells and, in turn, MAIT cells limit neutrophil survival. |
| Databáze: | OpenAIRE |
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