Pharmacokinetics of amdinocillin and pivamdinocillin in normal volunteers
| Autor: | Harold C. Neu, Carmen Ortiz-Neu, James G. Christenson, Elliot L. Francke, Subramaniam Srinivasan |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Metabolic Clearance Rate Administration Oral Biological Availability Penicillanic Acid Absorption (skin) Urine Pharmacology Models Biological High-performance liquid chromatography chemistry.chemical_compound Pharmacokinetics Oral administration Humans Medicine Infusions Parenteral business.industry Amdinocillin Amdinocillin Pivoxil General Medicine Bioavailability Kinetics Pivmecillinam chemistry Anesthesia business |
| Zdroj: | The American Journal of Medicine. 75:60-64 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(83)90095-5 |
| Popis: | The pharmacokinetic parameters of amdinocillin and pivamdinocillin were studied in 12 normal volunteers. Plasma amdinocillin concentrations were determined by microbiologic assay and urine concentrations by high performance liquid chromatography. Pharmacokinetic parameters were calculated by a two-compartment open model for the intravenous infusion and by a one-compartment model with zero-order absorption for the oral doses. The mean peak serum level after the intravenous infusion of 500 mg was 39 micrograms/ml. At one and a half hours after the oral administration of 250 mg and 500 mg doses, mean peaks were 1.93 and 2.66 micrograms/ml respectively. Half-life was one hour for all doses. Maximal plasma concentration did not increase proportionally with dose. Bioavailability was 45 percent after the 250 mg dose and 38 percent after the 500 mg dose. |
| Databáze: | OpenAIRE |
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