A regioselective reductive cleavage of benzylidene acetal: stereoselective synthesis of N-Boc-protected cis-(2R,3S)-3-hydroxy pipecolic acid

Autor:	Sundarababu Baskaran, Ponminor Senthil Kumar
Rok vydání:	2009
Předmět:	chemical reaction Chemistry Stereochemistry Organic Chemistry Acetal stereochemistry Regioselectivity Piperidine derivative piperidine derivative pipecolic acid derivative Biochemistry chemistry.chemical_compound Reductive cleavage Drug Discovery drug synthesis Stereoselectivity Hydroxymethyl benzylidene derivative glucose Pipecolic acid
Zdroj:	Tetrahedron Letters. 50:3489-3492
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2009.03.007
Popis:	A stereoselective synthesis of N-Boc-protected cis-(2R,3S)-3-hydroxy pipecolic acid, starting from d-glucose is described. The key step in the overall synthesis is a highly regioselective reductive cleavage of benzylidene acetal 13 leading to hydroxymethyl piperidine derivative 14. � 2009 Elsevier Ltd. All rights reserved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13859fafe445c67c2d8b1a634bf133af https://doi.org/10.1016/j.tetlet.2009.03.007 Zobrazit plný text záznamu Full Text from ScienceDirect