Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration
| Autor: | Yasmin Issa, Peter Altevogt, Luis H. Galindo, Daniel Nummer, Tobias Seibel, Susanne Sebens Müerköster, Moritz Koch, Friedrich-Hubertus Schmitz-Winnenthal, Philipp Beckhove, Juergen Weitz |
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| Rok vydání: | 2008 |
| Předmět: |
Endothelium
Antibodies Neoplasm Angiogenesis Neural Cell Adhesion Molecule L1 Adenocarcinoma Vascular endothelial growth inhibitor Cell Movement Drug Discovery Tumor Cells Cultured medicine Humans Neoplasm Metastasis Genetics (clinical) ICAM-1 Neovascularization Pathologic Cell adhesion molecule Chemistry Neuropilin-1 Neoplasm Proteins Cell biology Gene Expression Regulation Neoplastic Pancreatic Neoplasms Endothelial stem cell Vascular endothelial growth factor B Vascular endothelial growth factor A medicine.anatomical_structure Cancer research Cytokines Molecular Medicine |
| Zdroj: | Journal of Molecular Medicine. 87:99-112 |
| ISSN: | 1432-1440 0946-2716 |
| DOI: | 10.1007/s00109-008-0410-7 |
| Popis: | L1 cell adhesion molecule (L1CAM) is a transmembrane cell adhesion molecule initially defined as a promigratory molecule in the developing nervous system that appears to be also expressed in some endothelial cells. However, little is known about the functional role of L1CAM on endothelial cells. We observed that L1CAM expression was selectively enhanced on endothelium associated with pancreatic adenocarcinoma in situ and on cultured pancreatic tumor-derived endothelial cells in vitro. L1CAM expression of endothelial cells could be augmented by incubation with immunomodulatory cytokines such as tumor necrosis factor alpha, interferon gamma, or transforming growth factor beta 1. Antibodies to L1CAM and the respective ligand neuropilin-1 blocked tube formation and stromal cell-derived factor 1beta induced transmigration of tumor endothelial cells in vitro. L1CAM expression on tumor-derived-endothelial cells enhanced Panc1 carcinoma cell adhesion to endothelial cell monolayers and transendothelial migration. Our data demonstrate a functional role of L1CAM expression on tumor endothelium that could favor metastasis and angiogenesis during tumor progression. |
| Databáze: | OpenAIRE |
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