High prevalence anti-Trypanosoma cruzi antibodies, among blood donors in the State of Puebla, a non-endemic area of Mexico
| Autor: | M. Tibayrenc, Jean-François Guégan, Ricardo Pérez-Fuentes, María Del Carmen Sánchez-Guillén, J Martínez-Munguía, MI Rosas-Ramírez, Christian Barnabé, M Velásquez-Rojas, Hilda Salgado-Rosas, Enrique Torres-Rasgado |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Microbiology (medical)
Chagas disease Adult Veterinary medicine Blood transfusion lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 medicine.medical_treatment Trypanosoma cruzi lcsh:QR1-502 Antibodies Protozoan Enzyme-Linked Immunosorbent Assay lcsh:Microbiology Acquired immunodeficiency syndrome (AIDS) Seroepidemiologic Studies parasitic diseases medicine Prevalence Animals Humans Mexico Aged Hepatitis biology seroprevalence Transmission (medicine) business.industry autochthonous antigens Hemagglutination Tests Middle Aged biology.organism_classification medicine.disease Immunology Trypanosoma biology.protein blood donors Antibody Puebla business antibodies to Trypanosoma cruzi |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 97, Iss 7, Pp 947-952 (2002) ResearcherID Memórias do Instituto Oswaldo Cruz, Volume: 97, Issue: 7, Pages: 947-952, Published: OCT 2002 |
| ISSN: | 1678-8060 0074-0276 |
| Popis: | Blood transfusion is the second most common transmission route of Chagas disease in many Latin American countries. In Mexico, the prevalence of Chagas disease and impact of transfusion of Trypanosoma cruzi-contaminated blood is not clear. We determined the seropositivity to T. cruzi in a representative random sample, of 2,140 blood donors (1,423 men and 647 women, aged 19-65 years), from a non-endemic state of almost 5 millions of inhabitants by the indirect hemagglutination (IHA) and enzyme linked immunosorbent assay (ELISA) tests using one autochthonous antigen from T. cruzi parasites, which were genetically characterized like TBAR/ME/1997/RyC-V1 (T. cruzi I) isolated from a Triatoma barberi specimen collected in the same locality. The seropositivity was up to 8.5% and 9% with IHA and ELISA tests, respectively, and up to 7.7% using both tests in common. We found high seroprevalence in a non-endemic area of Mexico, comparable to endemic countries where the disease occurs, e.g. Brazil (0.7%), Bolivia (13.7%) and Argentina (3.5%). The highest values observed in samples from urban areas, associated to continuous rural emigration and the absence of control in blood donors, suggest unsuspected high risk of transmission of T. cruzi, higher than those reported for infections by blood e.g. hepatitis (0.1%) and AIDS (0.1%) in the same region. |
| Databáze: | OpenAIRE |
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