Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films
| Autor: | Yasushi Tamada, Sélène Rozet, Chuan Yin, Masaki Tanaka, Rino Okamoto, Hattori Hatsuhiko, Kondo Mikihisa, Hiromasa Sato, Toshihisa Tanaka, Shota Iino |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Biocompatibility General Chemical Engineering Modulus 02 engineering and technology physical properties lcsh:Chemistry Contact angle chemistry.chemical_compound Silicone Ultimate tensile strength General Materials Science Polyurethane 020502 materials cell attachment 021001 nanoscience & nanotechnology silicone modified polyurethane nanofibers cell proliferation lcsh:QD1-999 0205 materials engineering Chemical engineering chemistry Nanofiber cytotoxicity Elongation 0210 nano-technology |
| Zdroj: | Nanomaterials, Vol 9, Iss 3, p 367 (2019) Nanomaterials Volume 9 Issue 3 |
| ISSN: | 2079-4991 |
| Popis: | In this study, the physical properties and the biocompatibility of electrospun silicone-modified polyurethane (PUSX) nanofibers were discussed and compared with PUSX films. To investigate the effects of different structures on the physical properties, tensile strength, elongation at break, Young&rsquo s modulus, water retention, water contact angle (WCA) and thermal conductivity measurements were performed. To prove the in vitro biocompatibility of the materials, cell adhesion, cell proliferation, and cytotoxicity were studied by NIH3T3 mouse embryonic fibroblasts cells following by lactate dehydrogenase (LDH) analysis. As a conclusion, the mechanical properties, water retention, and WCA were proven to be able to be controlled and improved by adjusting the structure of PUSX. A higher hydrophobicity and lower thermal conductivity were found in PUSX nanofibers compared with polyurethane (PU) nanofibers and films. An in vitro biocompatibility evaluation shows that the cell proliferation can be performed on both PUSX nanofibers and films. However, within a short period, cells prefer to attach and entangle on PUSX nanofibers rather than PUSX films. PUSX nanofibers were proven to be a nontoxic alternative for PU nano-membranes or films in the biomedical field, because of the controllable physical properties and the biocompatibility. |
| Databáze: | OpenAIRE |
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