Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem

Autor: Xiaoping Yue, Yitong Li, Minjie Liu, Di Sang, Zedu Huang, Fener Chen
Rok vydání: 2022
Předmět:
Zdroj: Chemical Communications. 58:9010-9013
ISSN: 1364-548X
1359-7345
Popis: A ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution strategy was developed for the highly stereoselective and green synthesis of anti-aryl α-chloro β-hydroxy esters.
Databáze: OpenAIRE