Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem

Autor:	Xiaoping Yue, Yitong Li, Minjie Liu, Di Sang, Zedu Huang, Fener Chen
Rok vydání:	2022
Předmět:	Diltiazem Materials Chemistry Metals and Alloys Ceramics and Composites Esters Stereoisomerism General Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials
Zdroj:	Chemical Communications. 58:9010-9013
ISSN:	1364-548X 1359-7345
Popis:	A ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution strategy was developed for the highly stereoselective and green synthesis of anti-aryl α-chloro β-hydroxy esters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1378e102916b320603685291ffbadfb3 https://doi.org/10.1039/d2cc03102g Zobrazit plný text záznamu