Pre-transplant treatment of hepatocellular carcinoma: assessment of tumor necrosis in explanted livers
Autor: | Kathryn Tanaka, Steven Komura, Lansdale Lau, Linda L. Wong |
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Rok vydání: | 2004 |
Předmět: |
Adult
Male medicine.medical_specialty Necrosis Carcinoma Hepatocellular Waiting Lists Radiofrequency ablation medicine.medical_treatment Antineoplastic Agents Liver transplantation Injections Intralesional Gastroenterology law.invention law Internal medicine Preoperative Care Carcinoma Medicine Hepatectomy Humans Stage (cooking) Chemoembolization Therapeutic Retrospective Studies Transplantation Ethanol business.industry Liver Neoplasms Middle Aged medicine.disease Surgery Liver Transplantation Treatment Outcome Liver Doxorubicin Hepatocellular carcinoma Catheter Ablation Female medicine.symptom Percutaneous ethanol injection Cisplatin business Gels |
Zdroj: | Clinical transplantation. 18(3) |
ISSN: | 0902-0063 |
Popis: | Although liver transplantation (LT) is likely the most effective therapy for localized hepatocellular cancer (HCC), limited donor livers have resulted in prolonged waiting times for transplant. Pre-transplant therapy such as transarterial chemoembolization (TACE), percutaneous ethanol injection (PEI), and radiofrequency ablation (RFA) may be needed to sustain patients who are waiting. Records, imaging studies, and pathology to identify tumor necrosis on 15 explanted livers with HCC were reviewed. Forty-nine nodules were removed from 15 explanted livers. Five nodules in three livers that received no pre-transplant therapy were excluded from the study. Of the remaining 44 nodules in 12 patients, 29 (66%) had 75% or more tumor necrosis. Fifteen nodules in five patients had |
Databáze: | OpenAIRE |
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