Immunologic Responses to Vaccinia Vaccines Administered by Different Parenteral Routes
| Autor: | Shannon M. Harrison, David J. McClain, James D. Arthur, Jess A. Graham, John Cruz, Francis A. Ennis, Curtis L. Yeager, Michael S. Wright, Paul H. Gibbs, Peter L. Summers |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Injections Subcutaneous viruses Vaccinia virus Antibodies Viral Lymphocyte Activation Injections Intramuscular chemistry.chemical_compound Humans Immunology and Allergy Medicine Poxviridae Orthopoxvirus Neutralizing antibody Vaccinia Vaccine biology business.industry Viral Vaccine virus diseases ACAM2000 Viral Vaccines biology.organism_classification Virology Infectious Diseases chemistry Immunology biology.protein Female Vaccinia Intramuscular injection business |
| Zdroj: | The Journal of Infectious Diseases. 175:756-763 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/513968 |
| Popis: | To develop a less reactogenic but equally immunogenic vaccine, this study of 91 human volunteers compared the safety and immunogenic potency of a new, cell culture-derived vaccinia virus vaccine administered intradermally and intramuscularly with the licensed vaccinia vaccine administered by scarification. Cutaneous pox lesions developed in a higher proportion of scarification vaccinees. Scarification and intradermal vaccine recipients who developed cutaneous pox lesions had more local reactions but also achieved significantly higher cell-mediated and neutralizing antibody responses than those who did not develop pox lesions. Although less reactogenic, intradermal or intramuscular administration of vaccinia vaccine without the concomitant development of a cutaneous pox lesion induced lower immune responses. |
| Databáze: | OpenAIRE |
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