Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?
| Autor: | Rafael Bispo Paschoalini, Maria Aparecida Custódio Domingues, Cristiano Claudino Oliveira |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine Pathology medicine.medical_specialty lcsh:Medicine Vimentin Caspase 3 Histiocytic sarcoma Fas ligand Pathology and Forensic Medicine Proinflammatory cytokine 03 medical and health sciences Diagnosis Internal Medicine Medicine lcsh:RC31-1245 Letter to the Editor biology business.industry CD68 lcsh:R Immunohistochemistry medicine.disease 030104 developmental biology biology.protein business CD163 |
| Zdroj: | Autopsy and Case Reports, Vol 8, Iss 1 (2018) Autopsy & Case Reports |
| ISSN: | 2236-1960 |
| DOI: | 10.4322/acr.2018.001 |
| Popis: | Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases have morphological and immunohistochemical features consistent with the diagnosis of histiocytic sarcoma. The markers CD163, CD68, vimentin, lysozyme, and S-100 were positive in all cases. Similarly, the three samples were positive for Fas-ligand and Caspase-3. It is well-known that neoplasms may induce increased levels of Fas-ligand with the blockade of the apoptosis process. In the context of HS, the increased Fas-ligand expression represents a new area for research. Indeed, it is linked to proinflammatory stimulus and, maybe with the association of an infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|