Nickel essentiality, toxicity, and carcinogenicity
| Autor: | E. Denkhaus, K. Salnikow |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
inorganic chemicals
Male Transcription Genetic chemistry.chemical_element Toxicology Mice Species Specificity Nickel compounds Nickel Environmental health Neoplasms Metalloproteins Medicine Animals Homeostasis Humans Neoplastic transformation Carcinogen Cells Cultured Cocarcinogenesis Mechanism (biology) business.industry Drug Administration Routes Heavy metals Hematology Environmental exposure Environmental Exposure Neoplasms Experimental Body Fluids Rats Oxidative Stress Cell Transformation Neoplastic Oncology chemistry Toxicity Calcium Female business Signal Transduction |
| Zdroj: | Critical reviews in oncology/hematology. 42(1) |
| ISSN: | 1040-8428 |
| Popis: | The increasing utilization of heavy metals in modern industries leads to an increase in the environmental burden. Nickel represents a good example of a metal whose use is widening in modern technologies. As the result of accelerated consumption of nickel-containing products nickel compounds are released to the environment at all stages of production and utilization. Their accumulation in the environment may represent a serious hazard to human health. Among the known health related effects of nickel are skin allergies, lung fibrosis, variable degrees of kidney and cardiovascular system poisoning and stimulation of neoplastic transformation. The mechanism of the latter effect is not known and is the subject of detailed investigation. This review provides an analysis of the current state in the field. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect