Serum MMP-3 in rheumatoid arthritis: correlation with systemic inflammation but not with erosive status

Autor: V Péclat, J C Gerster, A M Chamot, Alexander So
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
Inflammation
Systemic inflammation
Stromelysin 1
Arthritis
Rheumatoid
Cohort Studies
Pathogenesis
Rheumatology
medicine
Humans
Pharmacology (medical)
Autoimmune disease
medicine.diagnostic_test
biology
business.industry
C-reactive protein
Adult *Arthritis
Rheumatoid/enzymology/immunology/pathology Biological Markers C-Reactive Protein/metabolism Cohort Studies Cross-Sectional Studies Extracellular Matrix/immunology Female Humans Inflammation/immunology Joints/enzymology/immunology/pathology Male Matrix Metalloproteinase 3/*blood Middle Aged
Middle Aged
medicine.disease
Extracellular Matrix
C-Reactive Protein
Cross-Sectional Studies
Rheumatoid arthritis
Erythrocyte sedimentation rate
Immunology
biology.protein
Female
Joints
Matrix Metalloproteinase 3
medicine.symptom
business
Biomarkers
Zdroj: Rheumatology, vol. 38, no. 5, pp. 407-10
Popis: OBJECTIVE: Metalloproteinases (MMP) play an important role in the remodelling of the extracellular matrix. However, evidence that they are responsible for tissue damage in pathological situations remains circumstantial. Stromelysin (MMP-3) production is increased in rheumatoid arthritis (RA), and has been proposed as a marker of joint damage. The relevance of serum levels of MMP-3 to erosions in RA was studied. METHODS: Fifty-three patients with active RA of > 5 yr duration and with available X-rays were stratified according to disease duration. Hand X-rays were scored for erosions. Patients were then classified into upper and lower quartiles. Serum MMP-3 levels were compared between these two groups. RESULTS: No significant differences in serum MMP-3 were seen between high and low eroders. A statistically significant correlation was observed between sMMP-3 and erthyrocyte sedimentation rate and C-reactive protein. CONCLUSIONS: Serum MMP-3 is not an independent marker of joint damage, but is correlated with systemic inflammation. Its precise role in joint damage in RA remains to be elucidated.
Databáze: OpenAIRE
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