Connecting the dots: chromatin and alternative splicing in EMT
| Autor: | Archana Dhasarathy, Jessica A. Warns, James R. Davie |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Epithelial-Mesenchymal Transition RNA Untranslated Transcription Genetic Exonic splicing enhancer Biology Biochemistry Article 03 medical and health sciences Splicing factor Exon Neoplasms RNA Precursors Histone code Humans RNA Messenger Molecular Biology Genetics Alternative splicing Intron Cell Biology Exons DNA Methylation Chromatin Assembly and Disassembly Chromatin Introns Cell biology Nucleosomes Histone Code Alternative Splicing 030104 developmental biology RNA splicing RNA Polymerase II Signal Transduction |
| Zdroj: | Biochemistry and cell biology = Biochimie et biologie cellulaire. 94(1) |
| ISSN: | 1208-6002 |
| Popis: | Nature has devised sophisticated cellular machinery to process mRNA transcripts produced by RNA Polymerase II, removing intronic regions and connecting exons together, to produce mature RNAs. This process, known as splicing, is very closely linked to transcription. Alternative splicing, or the ability to produce different combinations of exons that are spliced together from the same genomic template, is a fundamental means of regulating protein complexity. Similar to transcription, both constitutive and alternative splicing can be regulated by chromatin and its associated factors in response to various signal transduction pathways activated by external stimuli. This regulation can vary between different cell types, and interference with these pathways can lead to changes in splicing, often resulting in aberrant cellular states and disease. The epithelial to mesenchymal transition (EMT), which leads to cancer metastasis, is influenced by alternative splicing events of chromatin remodelers and epigenetic factors such as DNA methylation and non-coding RNAs. In this review, we will discuss the role of epigenetic factors including chromatin, chromatin remodelers, DNA methyltransferases, and microRNAs in the context of alternative splicing, and discuss their potential involvement in alternative splicing during the EMT process. |
| Databáze: | OpenAIRE |
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