Isodicentric chromosome 18q as sole abnormality in a histologically normal bone marrow from a patient with diffuse large-cell non-Hodgkin's lymphoma
| Autor: | Doris H. Wurster-Hill, Letha E. Mills, Bruce H. Davis, Edward D. Ball, James J. Vredenburgh |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Chromosome Disorders Biology Isodicentric Chromosome immune system diseases Bone Marrow hemic and lymphatic diseases Genetics medicine Humans Molecular Biology Chromosome Aberrations Pokeweed mitogen Large cell Lymphoma Non-Hodgkin medicine.disease Non-Hodgkin's lymphoma Lymphoma Chromosome Banding Normal bone Immunology Female Abnormality Chromosomes Human Pair 18 |
| Zdroj: | Cancer genetics and cytogenetics. 54(2) |
| ISSN: | 0165-4608 |
| Popis: | Cytogenetic analysis was performed on the histologically and immunophenotypically normal bone marrow (BM) of a 33-year-old woman with non-Hodgkin's lymphoma (NHL) before BM harvest. Unstimulated 24− and 48-hour cultures produced only normal metaphases. A pokeweed mitogen (PWM)—stimulated 48-hour culture, however, showed a clonal isodicentric chromosome 18q as the sole abnormality, suggesting a role for this approach in detection of submicroscopic BM involvement by B-cell NHL. |
| Databáze: | OpenAIRE |
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