ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research
| Autor: | Dierk Thomas, Milan Stengl, Dobromir Dobrev, Matteo E. Mangoni, Jordi Heijman, Carol Ann Remme, Larissa Fabritz, Katja E. Odening, Godfrey L. Smith, Cristina E. Molina, Leonardo Sacconi, A.M. Gomez, Antonio Zaza, Frank R. Heinzel |
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| Přispěvatelé: | Cardiologie, RS: Carim - H01 Clinical atrial fibrillation, RS: Carim - H04 Arrhythmogenesis and cardiogenetics, Cardiology, ACS - Heart failure & arrhythmias, APH - Methodology, University of Bern, Odening, K, Gomez, A, Dobrev, D, Fabritz, L, Heinzel, F, Mangoni, M, Molina, C, Sacconi, L, Smith, G, Stengl, M, Thomas, D, Zaza, A, Remme, C, Heijman, J |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
TORSADE-DE-POINTES Cardiac electrophysiology Medizin Cardiomyopathy Arrhythmias 030204 cardiovascular system & hematology 0302 clinical medicine BIO/09 - FISIOLOGIA Mechanisms Position paper Induced pluripotent stem cell LEFT-VENTRICULAR WALL SINOATRIAL NODE Atrial fibrillation Animal models 3. Good health PRESERVED EJECTION FRACTION Ion channels cardiovascular system HEART-FAILURE Mechanism Ion channel Electrophysiologic Techniques Cardiac Cardiology and Cardiovascular Medicine Experimental models PLURIPOTENT STEM-CELLS Arrhythmia Myocarditis Cellular electrophysiology LONG-QT SYNDROME 03 medical and health sciences [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Physiology (medical) SINUS NODE DYSFUNCTION medicine Animals Humans Animal model Experimental model business.industry TRANSGENIC RABBIT MODEL Cardiac arrhythmia Models Theoretical medicine.disease Electrophysiological Phenomena 030104 developmental biology Heart failure ATRIAL-FIBRILLATION business Neuroscience |
| Zdroj: | EP Europace, 23(11), 1795-1814. Oxford University Press Europace, 23(11), 1795-1814. Oxford University Press EP-Europace EP-Europace, Oxford University Press (OUP): Policy B, 2021, 23 (11), pp.1795-1814. ⟨10.1093/europace/euab142⟩ |
| ISSN: | 1532-2092 1099-5129 |
| DOI: | 10.1093/europace/euab142 |
| Popis: | Cardiac arrhythmias are a major cause of death and disability. A large number of experimental cell and animal models have been developed to study arrhythmogenic diseases. These models have provided important insights into the underlying arrhythmia mechanisms and translational options for their therapeutic management. This position paper from the ESC Working Group on Cardiac Cellular Electrophysiology provides an overview of (i) currently available in vitro, ex vivo, and in vivo electrophysiological research methodologies, (ii) the most commonly used experimental (cellular and animal) models for cardiac arrhythmias including relevant species differences, (iii) the use of human cardiac tissue, induced pluripotent stem cell (hiPSC)-derived and in silico models to study cardiac arrhythmias, and (iv) the availability, relevance, limitations, and opportunities of these cellular and animal models to recapitulate specific acquired and inherited arrhythmogenic diseases, including atrial fibrillation, heart failure, cardiomyopathy, myocarditis, sinus node, and conduction disorders and channelopathies. By promoting a better understanding of these models and their limitations, this position paper aims to improve the quality of basic research in cardiac electrophysiology, with the ultimate goal to facilitate the clinical translation and application of basic electrophysiological research findings on arrhythmia mechanisms and therapies. |
| Databáze: | OpenAIRE |
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