Autoantibodies stabilize neutrophil extracellular traps in COVID-19
| Autor: | Yogendra Kanthi, Srilakshmi Yalavarthi, Alyssa Harbaugh, Claire K Hoy, Melanie Zuo, Hui Shi, Kelsey Gockman, Jason S. Knight, Sherwin Navaz, Yu Zuo, Jacqueline A. Madison |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent Coronavirus disease 2019 (COVID-19) Neutrophils Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Adaptive immunity Autoimmunity medicine.disease_cause Extracellular Traps Article Young Adult Immunopathology Humans Medicine Autoantibodies biology SARS-CoV-2 business.industry Autoantibody COVID-19 General Medicine Neutrophil extracellular traps Oxygenation Middle Aged Acquired immune system Immunoglobulin M Immunoglobulin G Immunology biology.protein Female Calprotectin Antibody business Research Article |
| Zdroj: | JCI Insight medRxiv |
| ISSN: | 2379-3708 |
| Popis: | The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils is recognized to play an important role in the thromboinflammatory milieu inherent to severe presentations of COVID-19. At the same time, a variety of functional autoantibodies have been observed in individuals with severe COVID-19 where they likely contribute to immunopathology. Here, we aimed to determine the extent to which autoantibodies might target NETs in COVID-19 and, if detected, to elucidate their potential functions and clinical associations. We measured anti-NET antibodies in 328 individuals hospitalized with COVID-19 alongside 48 healthy controls. We found high anti-NET activity in the IgG and IgM fractions of 27% and 60% of patients, respectively. There was a strong correlation between anti-NET IgG and anti-NET IgM (r=0.4, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|