Influence of gender and menopausal status on gut microbiota
| Autor: | María M. Malagón, Oriol A. Rangel-Zuñiga, Antonio Camargo, Jose Lopez-Miranda, Gracia M. Quintana-Navarro, Rosa Jimenez-Lucena, Manuel Tena-Sempere, Jose A. Santos-Marcos, Blanca B. Landa, Francisco Pérez-Jiménez, Pablo Perez-Martinez, Sonia García-Carpintero |
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| Rok vydání: | 2018 |
| Předmět: |
Leptin
Male 0301 basic medicine Physiology 030209 endocrinology & metabolism Gut flora General Biochemistry Genetics and Molecular Biology Body Mass Index 03 medical and health sciences 0302 clinical medicine Glucagon-Like Peptide 1 medicine Humans Chemokine CCL2 Sex Characteristics biology Adiponectin Interleukin-6 business.industry Obstetrics and Gynecology Middle Aged biology.organism_classification medicine.disease Obesity Gastrointestinal Microbiome Sexual dimorphism 030104 developmental biology Female Menopause Roseburia business Body mass index Hormone |
| Zdroj: | Maturitas. 116:43-53 |
| ISSN: | 0378-5122 |
| Popis: | Objectives We explore the differences in the gut microbiota associated with gender and hormonal status. Study design We included 76 individuals in this study: 17 pre-menopausal women, 19 men matched by age, as a control group for the pre-menopausal women, 20 post-menopausal women and 20 men matched by age as a control group for the post-menopausal women; all 4 groups were also matched by body mass index (BMI) and nutritional background. Main measurements We analyzed the differences in the gut microbiota, endotoxemia, intestinal incretins, pro-inflammatory cytokines, and plasma levels of energy homeostasis regulatory hormones between pre- and post-menopausal women and compared them with their respective male control groups. Results We found a higher Firmicutes/Bacteroidetes ratio, a higher relative abundance of Lachnospira and Roseburia, and higher GLP-1 plasma levels in pre-menopausal women than in post-menopausal women, who had similar levels to men. In contrast, we observed a lower relative abundance of the Prevotella, Parabacteroides and Bilophila genera, and IL-6 and MCP-1 plasma levels in pre-menopausal women than in post-menopausal women, who had similar levels to the men. We also found higher GiP and leptin plasma levels in women than in men, irrespective of the menopausal status of the women. In addition, adiponectin levels were higher in pre-menopausal women than in their corresponding age-matched male control group. Conclusions Our results suggest that the differences in the composition of gut microbiota between genders and between women of different hormonal status may be related to the sexual dimorphism observed in the incidence of metabolic diseases and their co-morbidities. |
| Databáze: | OpenAIRE |
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