Inhaled Particulate Matter Causes Expression of Nuclear Factor (NF)- κ B–Related Genes and Oxidant-Dependent NF- κ B Activation In Vitro

Autor:	Kevin E. Driscoll, Pamela M. Vacek, Brooke T. Mossman, Terry Gordon, Arti Shukla, Willie J. McKinney, Cynthia R. Timblin, Kelly Ann Berube
Rok vydání:	2000
Předmět:	Male Transcriptional Activation Pulmonary and Respiratory Medicine Clinical Biochemistry Cell Line Alveolar cells Interferon-gamma Mice Transforming Growth Factor beta Gene expression medicine Animals RNA Messenger Particle Size Interleukin 6 Lung Lymphotoxin-alpha Molecular Biology Inhalation exposure Air Pollutants Inhalation Exposure Mice Inbred C3H biology Interleukin-6 Tumor Necrosis Factor-alpha NF-kappa B Epithelial Cells DNA Cell Biology Transforming growth factor beta Fluoresceins Oxidants NFKB1 Molecular biology Carbon Mice Inbred C57BL medicine.anatomical_structure Gene Expression Regulation Immunology biology.protein Tumor necrosis factor alpha Macrophage migration inhibitory factor Protein Binding
Zdroj:	American Journal of Respiratory Cell and Molecular Biology. 23:182-187
ISSN:	1535-4989 1044-1549
DOI:	10.1165/ajrcmb.23.2.4035
Popis:	High levels of ambient air pollution are associated with exacerbation of asthma and respiratory morbidity, yet little is known concerning the mechanisms of inflammation and toxicity by components of inhaled particulate matter (PM). Brief inhalation of PM(2.5) (particles of an aerodynamic diameter of < 2.5 microns) (300 microg/m(3) air for 6 h followed by a period of 24 h in clean air) by either C3H/HeJ or C57/BL6 mice caused significant (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136aafa0cb83f57eedae5e796b3802bb https://doi.org/10.1165/ajrcmb.23.2.4035 Zobrazit plný text záznamu