Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt’s lymphoma: a case report and review of the literature

Autor: Gabriele Pozzato, Stella Bernardi, Veronica Calabrò, Deborah Bonazza, Bruno Fabris, Fabrizio Zanconati, Andrea Michelli
Přispěvatelé: Bernardi, Stella, Michelli, Andrea, Bonazza, Deborah, Calabrò, Veronica, Zanconati, Fabrizio, Pozzato, Gabriele, Fabris, Bruno
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Thyroid nodules
medicine.medical_specialty
endocrine system
Burkitt’s lymphoma
endocrine system diseases
Thyroid lymphomas
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Thyroid Gland
030209 endocrinology & metabolism
Case Report
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Case report
Core needle biopsy
Thyroid
03 medical and health sciences
Endocrinology
0302 clinical medicine
Cytology
hemic and lymphatic diseases
Thyroid lymphoma
Biopsy
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Thyroid Neoplasms
Thyroid Nodule
Chemotherapy
lcsh:RC648-665
medicine.diagnostic_test
business.industry
Nodule (medicine)
General Medicine
Middle Aged
medicine.disease
Burkitt Lymphoma
Lymphoma
Diabetes and Metabolism
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Radiology
Biopsy
Large-Core Needle
medicine.symptom
business
Burkitt's lymphoma
Zdroj: BMC Endocrine Disorders
BMC Endocrine Disorders, Vol 18, Iss 1, Pp 1-7 (2018)
ISSN: 1472-6823
Popis: Background Thyroid lymphomas are an exceptional finding in patients with thyroid nodules. Burkitt’s lymphoma is one of the rarest and most aggressive forms of thyroid lymphomas, and its prognosis depends on the earliness of medical treatment. Given the rarity of this disease, making a prompt diagnosis can be challenging. For instance, fine-needle aspiration (FNA) cytology, which is the first-line diagnostic test that is performed in patients with thyroid nodules, is often not diagnostic in cases of thyroid lymphomas, with subsequent delay of the start of therapy. Case presentation Here we report the case of a 52-year-old woman presenting with a rapidly enlarging thyroid mass. Thyroid ultrasonography demonstrated a solid hypoechoic nodule. FNA cytology was only suggestive of a lymphoproliferative disorder and did not provide a definitive diagnosis. It is core needle biopsy (CNB) that helped us to overcome the limitations of routine FNA cytology, showing the presence of thyroid Burkitt’s lymphoma. Subsequent staging demonstrated bone marrow involvement. The early start of an intensive multi-agent chemotherapy resulted in complete disease remission. At 60 months after the diagnosis, the patient is alive and has not had any recurrence. Conclusions Clinicians should be aware that thyroid Burkitt’s lymphoma is an aggressive disease that needs to be treated with multi-agent chemotherapy as soon as possible. To diagnose it promptly, they should consider to order/perform a CNB in any patient with a rapidly enlarging thyroid mass that is suspicious for lymphoma.
Databáze: OpenAIRE
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