Hepatic enzyme ALT as a marker of glucose abnormality in men with cystic fibrosis

Autor: Kenneth Cusi, Adèle Coriati, Silvia R Netedu, Valérie Boudreau, Johann Colomba, Rémi Rabasa-Lhoret, Julio A. Leey, Catherine Lehoux-Dubois, François Tremblay
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Blood Glucose
Male
Cystic Fibrosis
Pulmonology
Physiology
medicine.medical_treatment
Oral Glucose Suppression Test
Type 2 diabetes
Gastroenterology
Biochemistry
Liver disease
0302 clinical medicine
Endocrinology
Liver Function Tests
Medicine and Health Sciences
Insulin
030212 general & internal medicine
Glucose Tolerance
Glucose tolerance test
Multidisciplinary
medicine.diagnostic_test
Liver Diseases
Fatty liver
Alanine Transaminase
3. Good health
Liver
Genetic Diseases
Medicine
Female
Research Article
Adult
medicine.medical_specialty
Endocrine Disorders
Science
030209 endocrinology & metabolism
Gastroenterology and Hepatology
03 medical and health sciences
Young Adult
Autosomal Recessive Diseases
Diagnostic Medicine
Internal medicine
Diabetes mellitus
Glucose Intolerance
medicine
Diabetes Mellitus
Humans
Glycemic
Diabetic Endocrinology
Clinical Genetics
Pharmacology
Endocrine Physiology
business.industry
Biology and Life Sciences
Glucose Tolerance Test
medicine.disease
Fibrosis
Hormones
Pharmacologic-Based Diagnostics
Fatty Liver
Metabolism
Glucose
Glucose Tolerance Tests
Metabolic Disorders
Insulin Resistance
business
Liver function tests
Biomarkers
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0219855 (2019)
ISSN: 1932-6203
Popis: AimCystic fibrosis (CF) patients are at high risk of developing CF-related diabetes (CFRD). In non-CF patients, liver disease, specifically steatosis and non-alcoholic fatty liver disease (NAFLD), is strongly associated with type 2 diabetes. We compared glycemic status and metabolic profiles in CF patients according to a biomarker of hepatic injury, alanine aminotransferase (ALT).MethodsWe conducted a cross-sectional study among 273 adult CF patients recruited from the Montreal CF Cohort. A 2-hour oral glucose tolerance test (OGTT) was performed to collect glucose and insulin measures every 30 minutes. Fasting ALT levels and anthropometric measures were also obtained. Patients were categorized into 2 groups based on ALT cut-off of 25 U/L.ResultsPatients in the high ALT group were mostly men (83%), had higher mean weight and BMI (pConclusionsAdult CF men with higher ALT show an increased frequency of dysglycemia and de novo CFRD, lower insulin sensitivity and higher eight. Our data suggests that ALT levels could be an interesting tool to guide targeted diabetes screening, particularly among CF men. Prospective studies are needed to confirm these observations.
Databáze: OpenAIRE
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